Planar cell polarity and the kidney
نویسندگان
چکیده
Planar cell polarity (PCP) is the uniform orientation and alignment of a group of cells orthogonal to the apical-basal axis within a tissue. Originally described in insects, it is now known that PCP is required for many processes in vertebrates, including directional cell movement, polarized cell division, ciliary orientation, neural tube closure, heart development and lung branching. In this review, we outline the evidence implicating PCP in kidney development and disease focusing initially on the function of PCP in ureteric bud branching and elongation. We then describe how defects in PCP may lead to polycystic kidney disease and discuss a newly identified role for PCP in the kidney filtration barrier.
منابع مشابه
Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia.
Polycystic kidney disease (PKD) is an inherited disorder that is characterized by the accumulation of cysts in the renal parenchyma and progressive decline in renal function. Recent studies suggest that PKD arises from abnormalities of the primary cilium. We have previously shown that kidney-specific inactivation of the ciliogenic gene Kif3a during embryonic development produces kidney cysts an...
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ease. Nat Genet 38: 21–23, 2006 16. Nishio S, Tian X, Gallagher AR, Yu Z, Patel V, Igarashi P, Somlo S: Loss of oriented cell division does not initiate cyst formation. J Am Soc Nephrol 21: 295–302, 2010 17. Karner C, Wharton KA Jr, Carroll TJ: Planar cell polarity and vertebrate organogenesis. Semin Cell Dev Biol 17: 194–203, 2006 18. Karner CM, Chirumamilla R, Aoki S, Igarashi P, Wallingford ...
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